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In an effort to improve the activity, a series of 4/3-aminoacetophenones and derived thiosemicarbazones were reported for their inhibitory activity of mushroom tyrosinase 102

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The mechanism responsible for the inhibitory effect of high GSH concentrations on the rate of H 2 O 2 formation is unclear, but it may involve a competitive inhibition of CSH binding to the SOD1 active-site by GSH 65